
On his return in 1545, he assisted the prominent physician Louis Serre in his fight against a major plague outbreak in Marseille and then tackled further outbreaks of disease on his own in Salon-de-Provence and in the regional capital, Aix-en-Provence. Finally, in 1547, he settled in Salon-de-Provence in the house that exists today, where he married a rich widow named Anne Ponsarde, with whom he had six children—three daughters and three sons. Between 1556 and 1567 he and his wife acquired a one-thirteenth share in a huge canal project, organized by Adam de Craponne, to create the Canal de Craponne to irrigate the largely waterless Salon-de-Provence and the nearby Désert de la Crau from the river Durance
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