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Lisa and Francesco had five children: Piero, Piera, Camilla, Marietta, and Andrea between 1496 and 1502. Lisa lost a baby daughter in 1499. Lisa also raised Bartolomeo, the son of Francesco, and his first wife Camilla di Mariotto Rucellai, who died shortly after the birth. The second wife of Lisa's father, Caterina di Mariotto Rucellai, and Francesco's first wife were sisters, members of the Rucellai family
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