Virginia married her cousin at the age of 13 to the famous American writer Edgar Allan Poe, and in 1847, at the age of 24, she died of tuberculosis. He was first buried in the tomb of the family from whom the couple rented their cottage in Fordham, near New York.
The cemetery was demolished in 1875, and a few years later William Gill, a biographer of the Poe family, apparently became the owner of the cemetery when the custodian wanted to throw it away. Gill kept the bones in a box under his bed for a while. Virginia's bones were buried with her husband five years later in the tomb built for the author in 1875 at Westminster Hall Cemetery (now part of the University of Maryland Law School in Baltimore).