Nafiseh Roshan's first performance was in a high school play titled Towards Happiness in 10th grade for which she won a Plaque of Honor from the regional Office of the Education Ministry. After entering university, she participated in a performing arts class and seriously began to pursue acting. Her first television appearance was in the drama Memorable Days in the summer of 2003. After graduating from university, she appeared in the dramas Qarib's World, Unconsciousness and The Years of Snow and Violet. She has also appeared in a number of television movies.